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"Buried In The Files"
The solution to the global animal overpopulation problem might be "buried in the files."
One way to find the solution may be to conduct an extensive literature review. Tens of thousands of chemicals have been tested over the years as pharmaceutical companies search for formulas to treat thousands of problems from AIDS to malaria.
In the course of thousands of tests using thousands of chemicals, it is likely that at least one of these tests revealed sterility as an unwanted side effect.
Because the chemical being tested at the time had nothing to do with sterility, such as testing a chemical to treat headaches, the sterility side effect may have been simply noted and ultimately disregarded -- and its possible use for stray dog populations was not considered or recognized and thus not acted upon. The formula may have been abandoned for unrelated reasons, causing the results to be filed away or "buried" in the files.
In short, we want to search through thousands of pages of these documented side effects, looking for words such as sterility or impotence, etc.
We are looking for any test result showing sterility as a side effect.
Theoretical example: Company ABC was testing chemical #1000 in 1960 with the hope of marketing this chemical as a cure for diabetes. Tests showed that this chemical had three unwanted side effects, and side effect #1 was extreme stuttering and the inability to speak clearly. This side effect was considered serious enough to lead the company to abandon the chemical and file away the test data. However, also in the test data is
side effect #4 - sterility.
Since the intended purpose of the chemical was to cure diabetes, in 1960 sterility was just considered a negative side effect at the time, and not acted upon.
Today, 28 years later, if we can look through the data files and "find" the sterility side effect, we could then use that chemical to solve animal over population problems.
Prior to being given access to the data, we would enter into agreements with the companies owning the data, using our Standard Agreement, as described below.
There are approximately 100 variations of birth control drugs which have already been approved of for use in humans.
We will focus first on data resulting from human birth control pills that were tested on dogs, searching for any side effects that caused long-term sterility in the tested dogs or other animals.
Theoretical example: It is possible that in the process of testing these birth control drugs for humans, one of the negative side effects of a first generation of birth control drug #15 -- an early version of drug #15 -- was that it caused permanent sterility in the dogs used as test subjects.
Therefore, the first generation of birth control drug #15 was abandoned because of this extreme side effect -- or for any number of other side effects. Subsequently, changes were made to drug #15, thus transforming it into a second generation, or later, different version. The second generation version of the drug no longer had the negative side effect of permanent sterility in dogs. In this type of situation, we are interested in finding the first generation version -- the version that was abandoned.
Where is this data kept?
Libraries in which pharmaceutical companies keep the files of their test results/data are known as compound libraries. Conducting a review of data in compound libraries to look for formulas that caused at least some sterility as a side effect could provide us with the answer we are looking for.
We are in contact with most of the leaders in this field (chemical sterilization), and to the best of our knowledge, a review such as this has not yet been conducted.
One exceptional leader in the field, Dr. Gary Michelson, has informed us that in the near future he hopes to embark on his own review of compound libraries, for the same reasons. When he does, we will do everything possible to unite our efforts.
We anticipate that this compound review should take at least 24 months to complete, depending on the level and speed of cooperation of the pharmaceutical companies.
One of the first steps will be to expeditiously canvass the entire scientific community in this field to determine if anyone has ever conducted such a review and if so, obtain access to any of their findings. This will include extensive research into publicly-available scientific literature outside of compound libraries, as well as interviews with many scientists.
Using our Standard Agreement, we will retain a Senior Scientist who will: (a) be a professor already employed by a university; and who (b) can provide at least three to four doctoral students to perform a large portion of the work.
Standard Agreement. In general terms, it will be agreed that for any patents resulting from this work:
1. The other party will receive the exclusive rights to market the contraceptive to the private sector (i.e., veterinarians, pet owners);
2. We will retain the exclusive rights to freely use the product to treat the stray animal populations of the world;
3. A predetermined portion of any proceeds from any patents will be used to reimburse our underwriters.
Strategy for Budgeting and Staffing
Our first hurdle is that there are vast amounts of data to be reviewed.
Our second hurdle is that much of the data is locked up in private libraries, and we will have to negotiate access to this data.
Thirdly, once we have access to portions of this vast amount of data, we will need people with science backgrounds - to be approved of by the drug companies -- to review the data. We also want to ensure that our review of the scientific data is reliable and accurate.
Therefore, to maximize resources the Project Director will first recruit the V.P. for University and Pharmaceutical Partnerships, in order to be able to gain quick and direct access to a maximum number of universities and drug companies.
This quick and direct access will put us in the best position to recruit the best V.P. for Scientific Accuracy from the many existing universities and drug companies.
At the same time we will begin the process of securing "Professor Partnerships" - our term for recruiting a university professor and his or her team of science-based doctoral level students. These students will perform the day-to-day research and will work for the project.
This will provide a significant value and cost-savings to us because the professor is already paid for by the university (as a salaried employee), and the doctoral students typically work without pay, as their compensation is in securing their medical degree.
We must negotiate the terms to secure the participation of each professor -- one professor per department or per university. The more we can afford, the better.
Success with this project can solve the following problems:
1. In the next five years, between $15 billion and $50 billion in costs will be incurred and paid by charities, taxpayers and private citizens to deal with the problems caused by dog and cat over-population in the U.S. alone, with a minimum of $3.2 billion being spent each year.
2. Four to five million dogs and cats are euthanized each year due to pet over-population in the U.S. alone.
3. In the U.S. there is a stray cat over-population of close to 100 million. Globally, between 400 million and 600 million stray dogs suffer daily; millions are inhumanely killed each year.
4. There are 55,000 humans who die each year from rabies, the vast majority of which results from being bitten by infected stray dogs. All four of these problems, and more, are due to dog and cat over-population, and all can be resolved by the creation of one or more long-lasting birth control pills.
Background on a Solution to these Problems
We want to find a chemical formula that causes permanent sterility or long-lasting contraception -- in pill form --that can be administered by using proven oral baiting techniques to the wild populations of stray dogs and cats.
This can solve the over-population problem. It will cause these populations to "crash" within a few years of proper application.
Example: Stray dogs stay in one neighborhood most of their lives; they breed only once every six months; and they live only an average of three years. In simple terms, the proper administration of oral contraceptives to these populations once every six months, over three years, can dramatically reduce and eventually end this over-population.
Staffing
Project Director
Responsible for:
Raising funds needed to ensure the completion and success of the Project;
Planning, organizing, implementing, overseeing and ensuring the success of the entire Project;
Recruiting all key staff and partners, starting with the V.P. for Partnerships and the V.P. for Scientific Accuracy;
Negotiating and securing binding Agreements with all parties (universities, pharmaceutical companies, etc.);
Providing executive support to all senior staff and all university and pharmaceutical partners.
V.P. for University and Pharmaceutical Partnerships
Responsible for:
Recruiting all needed scientists, professors, universities and colleges to perform the scientific reviews;
Soliciting all pharmaceutical companies, globally;
Securing the participation of as many pharmaceutical companies as possible, globally;
Liaising and coordinating all work between our scientific staff and the pharmaceutical representatives.
V.P. for Scientific Accuracy
Responsible for:
Ensuring that all scientific aspects of the work are correct and accurate;
Ensuring that all scientific findings, data and conclusions, are correctly interpreted and understood;
Consulting closely with and advising the Project Director on all important matters on a daily basis;
Directing and overseeing the day-to-day scientific data review work of all doctoral students and staff;
Spot-checking and monitoring the review of all test results and data by all staff.
University Professors
Responsible for:
Securing qualified doctoral-level students to perform the day-to-day scientific reviews;
Reviewing the findings of the doctoral-level students;
Working closely with the V.P. for Scientific Accuracy.
Summary
Two years from today, for a one-time investment or donation we may have a long-term birth control formula that can:
a. begin to dramatically reduce the global dog and/or cat over-population problem;
b. be the beginning of the end of the vast amount of daily suffering endured by strays;
c. begin to end once and for all, the annual killing of millions of animals;
d. save private citizens over a billion dollars per year in surgeries;
e. save taxpayers billions of dollars each year, funds now spent on
animal control;
f. save charities hundreds of millions of dollars in annual costs; freeing them from the heavy burden of attempting to deal with over-population, and thus freeing up the time, attention and resources of tens of thousands of charities.
"Victory belongs to the most persevering." -- Napoleon |
